The Effect of Overweight and Obesity on Liver Biochemical Markers in Children and Adolescents

Magnus J. Johansen; Julie Gade; Stefan Stender; Christine Frithioff-Bøjsøe; Morten A. V. Lund; Elizaveta Chabanova; Henrik S. Thomsen; Oluf Pedersen; Cilius E. Fonvig; Torben Hansen; Jens-Christian Holm


J Clin Endocrinol Metab. 2020;105(2) 

In This Article


This study provides age- and sex-specific reference values for plasma concentrations of ALT, AST, LDH, GGT, bilirubin, and ALP derived from a populationbased cohort of Danish children and adolescents aged 6 to 18 years. We found that age and sex influence the patterns of these biochemical markers throughout childhood and adolescence. Obesity in children and adolescents is associated with elevated biochemical markers of liver damage, likely reflecting the effects of NAFLD. These findings emphasize the need for both efficient preventive and treatment strategies in pediatric populations with overweight and obesity.