Update: Radiologic-Pathologic Correlation of Hepatocellular Adenoma

Sadhna Dhingra MD, FCAP; Chakradhar Thupili, MD; Steven Chua, MD, PhD; Kaustubh Shirlakar MD; Srinivasa R Prasad, MD; Venkateswar R Surabhi, MD


Appl Radiol. 2019;48(6):21-29. 

In This Article


Hepatocellular adenomas are a diverse group of benign liver neoplasms with increased propensity to bleed and to undergo malignant transformation. Recent genetic studies have identified several subtypes with distinctive tumor genetics and pathways as well as specific risk factors and risks of complications. MRI plays a key role in the diagnosis and classification of HAs as well as in surveillance. Hepatocellular adenomas with β-catenin mutations frequently undergo malignant change, inflammatory HAs commonly bleed, and steatotic HAs typically portend a favorable prognosis. A knowledge of the clinical and imaging findings and associated complications of the subtypes of hepatocellular adenoma permit optimal patient management.