Laboratory Evaluation of Peripheral Neuropathy

K.H. Vincent Lau, MD


Semin Neurol. 2019;39(5):531-541. 

In This Article


This review provides a framework for laboratory testing for different types of peripheral neuropathy. It should be emphasized that other than in cases of classic presentation of chronic DSP, neurophysiological testing may be helpful in characterizing the peripheral neuropathy type prior to further laboratory evaluation. Similarly, neurophysiological testing is important in acute polyneuropathy except in cases of classic presentations of GBS. The general neurologist is tasked with efficiently evaluating underlying causes of peripheral neuropathy in a way that maximizes the chance of identifying a potentially treatable etiology, while minimizing healthcare costs and inconvenience to the patient.