Significance of Anti-Neutrophil Cytoplasmic Antibodies in Systemic Sclerosis

Jayne Moxey; Molla Huq; Susanna Proudman; Joanne Sahhar; Gene-Siew Ngian; Jenny Walker; Gemma Strickland; Michelle Wilson; Laura Ross; Gabor Major; Janet Roddy; Wendy Stevens; Mandana Nikpour


Arthritis Res Ther. 2019;21(57) 

In This Article


This study reveals a significant association between ANCA in SSc and ILD, pulmonary embolism, synovitis and overlap syndrome with other connective tissue diseases. Patients who are ANCA positive have increased mortality, independent of sex or age at diagnosis. These findings suggest that ANCA should be tested at baseline in SSc patients as it is associated with a worse prognosis and necessitates vigilant monitoring and follow-up.