Tramadol for the Treatment of Catheter-related Bladder Discomfort

A Randomized Controlled Trial

Shuying Li; Liping Song; Yushan Ma; Xuemei Lin

BMC Anesthesiol. 2018;18(194)

Conclusion

In conclusion, tramadol 1.5 mg/kg was more effective than tramadol 1 mg/kg in treating CRBD and reducing postoperative pain without significant side effects.

1 2 3 4 5 6

Next Section

Abbreviations
ANOVA: one-way analysis of variance; CRBD: catheter related bladder discomfort; PACU: post-anaesthesia care unit; VAS: visual analog scale

Acknowlegements
Not applicable.

Funding
No funding.

Availability of data and materials
The datasets are not publicly available, but available from the corresponding author on reasonable request.

Ethics approval and consent to participate
Ethical approval was obtained from China Ethics Committee of Registering Clinical Trials (ChiECRCT-20,180,059), address: West China Hospital, Sichuan University, NO. 37, Guo Xue Xiang, Chengdu, Sichuan, China. The trial was registered in the Chinese Clinical Trial Registry (ChiCTR1800016390, date of registration: 2018–5-30) prior to patient enrollment. Written informed consent was abtained from all patients.

Consent for publication
Not applicable.

Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Trial registration
ChiCTR1800016390. Registered on 30 May 2018.

Table 1. Patients characteristics and clinical data
	Group A	Group B	Group C
Number of patients (n)	30	30	30
Age (year)	35.9 ± 7.7	37.0 ± 8.2	36.6 ± 9.0
Weight (kg)	56.7 ± 5.2	55.3 ± 4.4	55.6 ± 5.2
Duration of surgery (min)	118.3 ± 32.8	122.0 ± 34.9	121.2 ± 35.8
Intra-operative sufentanil requirement (ug)	25.5 ± 7.4	26.0 ± 8.0	25.3 ± 8.1

Table 2. Incidence and severity of CRBD presented as numbers (n)
Time	T0			T1			T2			T3			T4
Group	A	B	C	A	B	C	A	B	C	A	B	C	A	B	C
Severity
No				0	0	0	0	0	7	5	4	13*	16	23	26***
Mild				0	0	6	6	10	14*	8**	18	13	12	7	4
Moderate	26	25	22	26	27	24	22	20	9	17**	8	4	2	0	0
Severe	4	5	8	4	3	0	2	0	0	0	0	0	0	0	0

*P < 0.05 for comparison between group C vs groups A and B. **P < 0.05 for comparison between group A vs groups B and C. ***P < 0.05 for comparison between group A vs group C. T0: 0 h, T1: 0.5 h, T2: 1 h, T3: 2 h, T4: 6 h postoperatively