Brooke-Spiegler Syndrome

Waseem Mohiuddin, BS; Jake Laun, MD; Wayne Cruse, MD


ePlasty. 2018;18(ic14) 

In This Article


A 52-year-old woman presented to the cutaneous clinic with multiple firm, rubbery, flesh-colored papules localized to the face. Biopsy confirmed trichoepitheliomas. Because of clinical and histological manifestations, the patient was suspected to have Brooke-Spiegler syndrome. Patient stated that she had had these lesions since she was a teenager and had had them biopsied in the past, with some shown to be basal cell carcinomas.