Vasoplegia Treatments: The Past, the Present, and the Future

Bruno Levy; Caroline Fritz; Elsa Tahon; Audrey Jacquot; Thomas Auchet; Antoine Kimmoun


Crit Care. 2018;22(52) 

In This Article

Vasoplegia Occurs in All Shock States

Although initially ascribed to septic shock, it is now apparent that the majority of mechanisms explaining or associated with vascular hyporesponsiveness to vasopressors (inflammation, nitric oxide (NO), potassium and calcium channels, adrenomedullin, and free radicals) are also common to hemorrhagic shock, cardiogenic shock (including in post-cardiopulmonary bypass patients), anaphylactic shock, and, more generally, during ischemia-reperfusion, such as cardiac arrest or multiple trauma.[3–5]