Randomized, Double-blind, Placebo-controlled Clinical Trial for Evaluating the Efficacy of Fractional CO2 Laser Compared With Topical Estriol in the Treatment of Vaginal Atrophy in Postmenopausal Women

Vera L. Cruz, MD; Marcelo L. Steiner, MD, PhD; Luciano M. Pompei, MD, PhD; Rodolfo Strufaldi, MD, PhD; Fernando L. Afonso Fonseca, PhD; Lucila H. Simardi Santiago, MD, PhD; Tali Wajsfeld, MD; Cesar E. Fernandes, MD, PhD


Menopause. 2018;25(1):21-28. 

In This Article


Fractional CO2 laser is an emerging treatment option for treating VVA symptoms, particularly for women with contraindication for hormone therapy. Fractional CO2 laser treatment consists of two or three sessions and its effects persisted during our 20-week follow-up. Fractional CO2 laser effects are similar to topical estriol and the combined treatment. These study findings, either of no differences between groups or differences between CO2 laser and local estrogen, should all be considered preliminary. Larger placebo-controlled studies evaluating medium- and long-term effects of fractional CO2 laser treatment are needed. A 1-year follow-up of this study population has been planned to evaluate long-term effects of the three treatments provided.