Relationship Between Human Papillomavirus and Penile Cancer

Implications for Prevention and Treatment

Laura C. Kidd; Sharon Chaing; Juan Chipollini; Anna R. Giuliano; Philippe E. Spiess; Pranav Sharma


Transl Androl Urol. 2017;6(5):791-802. 

In This Article


With increasing rates in our population, burden of HPV-related pre-malignant lesions will continue to affect a great proportion of our population. Increased patient education along with prevention strategies such us condom use, hygienic measures, smoking cessation, and avoidance of chronic inflammatory states can have considerable impact on pathogenesis of pre-cancerous lesions of the penis. Although, the adoption of HPV vaccination has led to some success in female HPV-related cancers, the results are yet to be elucidated in the male population. With vaccination programs aimed at adolescents and young adults, a decrease in the incidence of pre-malignant lesions and subsequent progression to penile cancer should be evident in the coming years. Longer prospective follow-up will be required to fully assess the benefit of widespread vaccine adoption in the male population. In the meantime, more translational research and collaboration is encouraged aiming to provide increased therapeutic options for a significantly morbid and rare disease with potentially preventive and curative pathways.