Table 1. Topical Agents for Psoriasis for Adults
|Agent||Hydrocortisone 1% ||Calcipotriene 0.005% (Dovonex® cream)||Tazarotene 0.05%, 0.1% (available in cream and gel) (Tazorac®)||Calcipotriene 0.005% and betamethasone dipropionate 0.064% (Taclonex® ointment)|
|Dosage||Apply thin layer to affected area once or twice daily||Apply thin layer to affected area twice daily||Recommended to start with 0.05% strength. Apply thin film to affected area once daily. With gel, apply thin layer at night to a maximum 20% body surface area.||Apply to affected area once daily for up to 4 weeks. Maximum weekly dose should not exceed 100 g. Treatment to more than 30% of body surface area is not recommended.|
|Estimated Cost per gram||$1.07||$5.61||$6.30||$12.17|
|Adverse Effects (list not exhaustive)||Long-term use can result in loss of effectiveness of drug and skin thinning||Skin irritation, rash, pruritus, dermatitis, worsening of psoriasis||Burning/stinging, pruritus, erythema, worsening of psoriasis, skin pain and irritation||Folliculitis, burning sensation of the skin|
|Efficacy||Mild plaque psoriasis||Moderate to severe plaque psoriasis||Plaque psoriasis||Plaque psoriasis|
|Special Notes||Available over-the-counter||Vitamin D3 derivative||Retinoid.
Contraindicated in pregnancy.
|Vitamin D3 derivative plus topical steroid. Also available as suspension.|
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Cite this: Advances in Psoriasis Research and Side-by-Side Treatment Review - Medscape - May 31, 2017.