Infection in Organ Transplantation

J. A. Fishman


American Journal of Transplantation. 2017;17(4):856-879. 

In This Article


Infection must be considered in the differential for changes in clinical status of transplant recipients even in the absence of common signs or symptoms of infection. Specific microbiological diagnosis is essential for appropriate therapy and to avoid drug toxicities. Management of transplant recipients is increasingly dependent on assays for pathogen-specific immune function and molecular microbiological assays deployed in organ donors and recipients. These tools and the complexity of transplant management provide a basis for practice of Transplant Infectious Disease. Despite advances, emerging infections, increasing antimicrobial resistance, new immunosuppressive regimens, and newer technologies including extracorporeal organ resuscitation will add new challenges to clinical management. Investigative approaches including pathogen-specific immunotherapies and risk stratification based on genetic polymorphisms of immunoregulatory pathways will allow the individualization of immunosuppression and prophylaxis.