Younger Donor Age Tied to Better Survival After Living-Donor Liver Transplant

By Reuters Staff

April 18, 2017

NEW YORK (Reuters Health) - In adult-to-adult living-donor partial liver transplantation (LDLT), younger donor age is associated with better recipient survival, researchers from Japan report.

Younger livers generally exhibit better regeneration after liver transplantation and hepatectomy, whereas older livers have a significant risk for reinfection and rapid progression of hepatitis C virus, resulting in lower rates of patient and graft survival in HCV-positive recipients.

Dr. Koichiro Hata from Kyoto University Graduate School of Medicine in Kyoto, Japan, and colleagues used data from 315 cases of primary adult-to-adult LDLT to investigate the impact of donor age on survival outcomes.

The cumulative recipient survival was significantly higher with donors in their 20s than in all the other donor groups, whereas recipient age did not significantly affect their own survival, the team reports in the Annals of Surgery, online March 10.

Survival was highest in the child-to-parent transplant group, despite the highest recipient age in this combination, and survival was lowest in the parent-to-child group, even though the recipient age was the youngest.

The presence of HCV infection did not influence survival.

In multivariate analyses, having donors in their 20s and the use of right-sided grafts were independently associated with better six-month recipient survival.

"Although further large-scale studies are required to validate the results of this study," the researchers conclude, "our results highlight the significance of liver age on partial liver transplantation outcome and will be clinically valuable in cases of adult LDLT and split liver transplantation.”

Dr. Hata did not respond to a request for comments.


Ann Surg 2017.