Ketamine Infusions for Pediatric Sedation and Analgesia

Marcia L. Buck, PharmD, FCCP, FPPAG


Pediatr Pharm. 2016;22(6) 

In This Article

Availability and Dosing Recommendations

Ketamine is available in 100 mg/mL 5 mL vials and 50 mg/mL 10 mL vials. It may be diluted to a concentration of 1 or 2 mg/mL with 5% dextrose or normal saline. For perioperative use or for sedation and analgesia during mechanical ventilation, an initial loading dose of 0.5–2 mg/kg may be followed by an infusion starting at 0.5 mg/kg/min.[3,6–10] Lower doses (0.1–0.3 mg/kg/hr) were used by Sheehy and colleagues for the treatment of chronic pain.[9]