Ketamine Infusions for Pediatric Sedation and Analgesia

Marcia L. Buck, PharmD, FCCP, FPPAG


Pediatr Pharm. 2016;22(6) 

In This Article

Warnings and Precautions

As a result of its sympathomimetic effects, ketamine is contraindicated in patients with clinically significant underlying hypertension. Cardiovascular function should be continually measured during administration in patients with any degree of cardiac disease. Ketamine may produce respiratory depression or apnea at higher doses or with rapid administration. Due to the potential for laryngospasm, ketamine should not be used alone in cases involving the pharynx, larynx, or bronchial tree.[3]

Ketamine is a class III controlled substance. Prolonged use may result the development of tolerance and dependence.[3] Withdrawal symptoms may occur after long-term use, but have not been well described in children.