Personalized Medicine for Chronic, Complex Diseases: Chronic Obstructive Pulmonary Disease as an Example

Josiah E Radder; Steven D Shapiro; Annerose Berndt


Personalized Medicine. 2014;11(7):669-679. 

In This Article

Future Perspective

Personalized medicine for chronic, complex diseases is on the cusp of becoming reality. Although we continue to lack important information about how to best define phenotypes and regarding the genetic variants involved in the pathogenesis of these phenotypes, the technology to explore both of these in novel ways is now available. Decreased costs of sequencing, advanced methods for storing these data, integrating them with the clinical record and conducting powerful retrospective studies with the combined data will soon further our understanding to a new level. The technological tools to return these evidence-based results to the bedside are also rapidly improving and are available on previously unprecedented levels. The concurrent development of all of these tools will usher in a new era for the personalized medicine of chronic diseases such as COPD in which we will be able to define subgroups for therapeutic success and improve the prediction of severity or prognosis and thereby improve quality and cost of care in ways that reflect the complexity of the disease process.