Personalized Medicine for Chronic, Complex Diseases: Chronic Obstructive Pulmonary Disease as an Example

Josiah E Radder; Steven D Shapiro; Annerose Berndt


Personalized Medicine. 2014;11(7):669-679. 

In This Article


Personalizing medicine for chronic, complex diseases such as COPD offers the promise of increased the quality of care for patients by better-targeted therapies, as well as decreased costs of care, but this promise faces significant barriers. Although these barriers are imposing, we believe that decreased costs in sequencing, the collection of health data on a previously unprecedented scale and improved technologies allowing for the integration of these data make this achievement possible for perhaps the first time in history. Increased utilization of the EHR in order to complement prospective, longitudinal studies for phenotyping and using this improved phenotyping in order to increase our understanding of the genetic variants involved with disease will significantly improve our ability to classify patients and so to better individualize treatment. Broader adoption of technologies such as carefully designed EDWs will be necessary in order to synthesize the information using analytics tools. Finally, CDSSs will return the discoveries made through these methods to patients at the bedside.