Biofilm-Based Infections in Long-term Care Facilities

Gianfranco Donelli; Claudia Vuotto


Future Microbiol. 2014;9(2):175-188. 

In This Article

Future Perspective

The large amount of data available today on biofilm-based HAIs is expected to provide positive answers to a number of open issues awaiting to be addressed, including:

  • The development of noninvasive methods for the in vivo sampling of biofilms in a 'soft' manner to save their tridimensional structure, to avoid any damage to the underlying tissues and to accurately measure biofilm thickness and other significant parameters. Reaching this target could greatly facilitate the study of microbial biofilms growing on infected pressure ulcers and the related treatment strategies;

  • Finding new antibiofilm compounds able to overcome the present limits of antimicrobial drugs available so far claiming to be active against sessile-growing bacteria but not having a clinically proven antibiofilm effect;

  • The discovery of novel, natural or synthetic agents able to interfere with the quorum-sensing mechanisms responsible for population density or able to disrupt the mature biofilm;

  • The development of advanced, indwelling medical devices refractory to microbial colonization, based on new antibiofilm coatings able to counteract microbial adhesion and biofilm formation on its polymeric surfaces.

The need to focus future research on the above-mentioned targets is based on the unsatisfactory clinical results so far associated with the antibiofilm use of the currently marketed antibiotic molecules and urinary- and intravascular-medicated catheters, as well as wound dressings and topical agents.