Predictors for Delayed Encephalopathy Following Acute Carbon Monoxide Poisoning

Kaoru Kudo; Kotaro Otsuka; Junko Yagi; Katsumi Sanjo; Noritaka Koizumi; Atsuhiko Koeda; Miki Yokota Umetsu; Yasuhito Yoshioka; Ayumi Mizugai; Toshinari Mita; Yu Shiga; Fumito Koizumi; Hikaru Nakamura; Akio Sakai


BMC Emerg Med. 2014;14(3) 

In This Article


The profile of cases at high risk of developing DNS is expected to include a clinical picture consisting of: the patient's selection of CO exposure as a means of suicide attempt in such serious mental condition as to affect his/her social and living functions; serious consciousness disturbance at admission due to acute CO poisoning, with a JCS score at or above 100; head CT findings indicating hypoxic encephalopathy; and abnormally high CK, CKMB and LDH levels detected by a blood test. In these cases, active consideration should be given to HBO therapy from an early stage after explaining to the patient's family members the risk of developing DNS, and at least five weeks' follow-up is believed necessary, during which due consideration should be given to the potential development of DNS.

The results of this study are tentative. Plans are to collect more substantiating data and conduct additional studies in the future.