Chronic Hepatitis B

A Treatment Update

Vincent Wong, MD; Henry Chan, MD


Semin Liver Dis. 2013;33(2):122-129. 

In This Article

Future Challenges

Current antiviral treatment for chronic hepatitis B is effective, but imperfect. Peginterferon is a finite treatment but is only successful in a minority of patients and carries numerous side effects. NAs are well-tolerated, but often require long-term treatment. Besides, some patients may still develop HCC and cirrhotic complications despite complete viral suppression. To further improve patient outcomes, we need new treatment strategies. On one hand, future drugs should have improved tolerability and durability. Treatment that can increase the chance of HBsAg seroclearance would be an immediate goal. On the other hand, treatment would have to target beyond the virus. For example, new insights in the pathogenesis of liver fibrosis may offer new therapeutic targets for cirrhosis regression.