Eribulin Mesylate

A Novel Halichondrin B Analogue for the Treatment of Metastatic Breast Cancer

Ali McBride, Pharm.D., M.S., BCPS; Sara K. Butler, Pharm.D., BCPS, BCOP

Disclosures

Am J Health Syst Pharm. 2012;69(9):745-755. 

In This Article

Dosage and Administration

The dosage of eribulin mesylate recommended by the manufacturer is 1.4 mg/m2 on days 1 and 8 of a 21-day cycle, with dosage reductions recommended for hepatic impairment and moderate renal impairment and dosage modifications recommended in patients with myelosuppression or other grade 3 or 4 nonhematologic toxicities.[21] Eribulin has additional properties that may be advantageous in the clinical setting, such as a rapid infusion time when compared with other microtubule-targeted agents. Because eribulin is a water-soluble compound, it does not require the use of lipophilic vehicles that can cause hypersensitivity reactions in patients; thus, premedication with corticosteroids and histamines is not required.[21,32] Eribulin mesylate is administered intravenously undiluted over two to five minutes or diluted in 100 mL of 0.9% sodium chloride injection and should not be administered in any solutions containing dextrose. Undiluted or diluted eribulin may be stored in a syringe or i.v. bag, respectively, for up to 4 hours at room temperature or up to 24 hours under refrigeration.[21]

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