Vaccines are effective at preventing infectious diseases and epidemics. There is no vaccine for M. leprae, but bacillus Calmette-Guérin (BCG), often used as a tuberculosis vaccine, also offers some protection against M. leprae, with a single dose providing 50% protection. Some have advocated adding killed M. leprae to the BCG vaccine for increased immunologic response, but trials of this strategy conducted in Malawi have not proved effective. Using BCG for prevention of Hansen's disease alone is not recommended at this time, and BCG is generally not recommended for any indication in the United States.
Pharmacotherapy. 2012;32(1):27-37. © 2012 Pharmacotherapy Publications