We conducted a comprehensive literature search of the MEDLINE database to identify all relevant studies published in English between 1959 and February 2011. The following medical subject heading terms and key words were used: dapagliflozin, SGLT2 inhibition, BMS-512148, type 2 diabetes mellitus, oral antidiabetic agents, hyperglycemia, and renal glucose reabsorption. All pertinent reviews and research reports were evaluated, and studies performed in both humans and animals were included. Other articles with information relevant to SGLT2 inhibition were also included. Because of the limited information available, abstracts and scientific presentations of phase III clinical studies not yet published were incorporated for completeness.
Pharmacotherapy. 2012;32(1):80-94. © 2012 Pharmacotherapy Publications