Management of Menorrhagia Associated With Chemotherapy-Induced Thrombocytopenia in Women With Hematologic Malignancy

Jill S. Bates, Pharm.D., M.S.; Larry W. Buie, Pharm.D.; C. Brock Woodis, Pharm.D.


Pharmacotherapy. 2011;31(11):1092-1110. 

In This Article

Effects of Chemotherapy on Gonadal Function

Gonadotoxicity secondary to chemotherapy is influenced by age at the time of treatment and type of treatment used. Ovarian failure is more likely to occur in older women. This may be based on the fact that long-term effects of chemotherapy have been shown to reduce follicle stores or cause ovarian atrophy. Furthermore, the peak number of oocytes occurs during gestation and naturally decreases with age.[22–24] Alkylating agents are strongly correlated with ovarian failure, and animal studies suggest that the risk of ovarian failure increases with dose. Acute effects of chemotherapy on gonadal function are not as well characterized but are thought to be related to apoptotic pathways for germ cell destruction.[23,25]


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