Management of Menorrhagia Associated With Chemotherapy-Induced Thrombocytopenia in Women With Hematologic Malignancy

Jill S. Bates, Pharm.D., M.S.; Larry W. Buie, Pharm.D.; C. Brock Woodis, Pharm.D.


Pharmacotherapy. 2011;31(11):1092-1110. 

In This Article

Diagnosis of Abnormal Uterine Bleeding

The diagnostic approach to abnormal uterine bleeding, including menorrhagia, consists of several different components. A targeted history and interview are essential in order to determine if a patient is experiencing ovulatory or anovulatory bleeding.[7] Additional aspects of diagnosis may include the clinical or physical evaluation, laboratory tests, pelvic ultrasound, magnetic resonance imaging, hysteroscopy, and endometrial biopsy.[19] Underlying causes for menorrhagia must be investigated. Some causes of menorrhagia include pregnancy and pregnancyrelated conditions, chronic endometritis, use of certain drugs (e.g., corticosteroids, tricyclic antidepressants, and herbal supplements such as ginkgo, ginseng, and soy), coagulopathies, blood dyscrasias (e.g., leukemia and thrombocytopenia), hepatic disease, polycystic ovary syndrome, and renal and thyroid diseases.[8,9]


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