Should We Screen Preterm Infants for Nephrocalcinosis? An Evidence-based Decision

Shahirose S Premji; Majeeda Kamaluddeen


Pediatr Health. 2010;4(1):24-35. 

In This Article

Kidney Size

Saarela et al. found kidney growth to be impaired (<2 standard deviation [SD]) unilaterally in one of 20 patients with nephrocalcinosis; none of the controls had impairment.[26] Comparison of renal length charted against height with published reference ranges for children 4–5 years of age showed no significant difference in kidney length between premature infants with nephrocalcinosis and matched controls without nephrocalcinosis.[27] By contrast, Kist-van Holthe et al.[28] reported kidney length to be significantly smaller for both preterm infants with and without nephrocalcinosis at a mean age of 7.5 years. It has been surmised that since the renal system continues to develop until 36 weeks, with peak nephrogenesis at 32 weeks, premature infants are at risk for renal growth impairment.[25,28] Nephrocalcinosis per se does not impair growth of the kidney.[25]


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