Diagnosis is typically based on presence of echogenicity in the medullary pyramids on ultrasound,[1,12] which has been shown to be sensitive in detecting early stages of nephrocalcinosis. These areas of increased echogenicity in the medullary pyramids have been subsequently confirmed on histology at autopsy as calcifications within the tubules or in the interstitium.[1,9,14] However, transient acute renal failure/transient renal dysfunction will also produce increased echogenicity of the medullary pyramids likely from precipitation of uric acid and is accompanied by oliguria. However, given its rapid resolution it can be ruled out on ultrasound repeated after 2 weeks.[9,15]
Pediatr Health. 2010;4(1):24-35. © 2010 Future Medicine Ltd.
Cite this: Should We Screen Preterm Infants for Nephrocalcinosis? An Evidence-based Decision - Medscape - Feb 01, 2010.