Should We Screen Preterm Infants for Nephrocalcinosis? An Evidence-based Decision

Shahirose S Premji; Majeeda Kamaluddeen


Pediatr Health. 2010;4(1):24-35. 

In This Article


Diagnosis is typically based on presence of echogenicity in the medullary pyramids on ultrasound,[1,12] which has been shown to be sensitive in detecting early stages of nephrocalcinosis.[13] These areas of increased echogenicity in the medullary pyramids have been subsequently confirmed on histology at autopsy as calcifications within the tubules or in the interstitium.[1,9,14] However, transient acute renal failure/transient renal dysfunction will also produce increased echogenicity of the medullary pyramids likely from precipitation of uric acid[15] and is accompanied by oliguria. However, given its rapid resolution it can be ruled out on ultrasound repeated after 2 weeks.[9,15]


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