At birth, the glomerular filtration rate is approximately 40 ml/minute/1.73 m2 in the fullterm neonate. This rate increases steadily to 50–75% of adult function by 6 months. Tubular secretion lags behind maturation of glomerular filtration by 7 months–1 year, leading to a glomerular-tubular maturational imbalance. Renal function fully matures by around 1 year of age. Transporter proteins participate in active renal excretion and reabsorption of many drugs; however, knowledge regarding their maturation remains scant. In general, weight-normalized doses of drugs excreted predominantly unchanged by the kidneys must be reduced for only neonates and infants. By 1 year of age, dosing based on body weight is similar in children and in adults.
Pharmacotherapy. 2009;29(6):680-690. © 2009
Cite this: Optimizing Pediatric Dosing: A Developmental Pharmacologic Approach - Medscape - Jun 01, 2009.