Use of Ursodiol in Infants and Children

Marcia L. Buck, Pharm.D., FCCP

Pediatr Pharm. 2009;15(2) 

In This Article

Summary

Ursodiol has proven to be a useful tool in the management of infants and children with hepatic and biliary dysfunction. In addition to improving bile flow, ursodiol may provide other protective effects. Over the past five years, several studies and case series in children have shown it to be beneficial, with a relatively mild adverse effect profile. Additional studies are needed to determine its benefit in improving hepatic function in children with biliary atresia and to define its role as prophylactic therapy in PNAC.

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