Use of Ursodiol in Infants and Children

Marcia L. Buck, Pharm.D., FCCP

Pediatr Pharm. 2009;15(2) 

In This Article


Ursodiol has proven to be a useful tool in the management of infants and children with hepatic and biliary dysfunction. In addition to improving bile flow, ursodiol may provide other protective effects. Over the past five years, several studies and case series in children have shown it to be beneficial, with a relatively mild adverse effect profile. Additional studies are needed to determine its benefit in improving hepatic function in children with biliary atresia and to define its role as prophylactic therapy in PNAC.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.