Use of Ursodiol in Infants and Children

Marcia L. Buck, Pharm.D., FCCP

Pediatr Pharm. 2009;15(2) 

In This Article

Drug Interactions

Antacids and bile acid sequestrants (colestipol and cholestyramine) may reduce the absorption of ursodiol and reduce its efficacy. Drugs that increase cholesterol secretion, such as clofibrate, estrogens, and oral contraceptives, may counteract the effects of ursodiol. Concomitant administration of these agents may blunt the efficacy of ursodiol in preventing gallstone formation. Lipid-lowering agents, such as HMGCoA reductase inhibitors, may also counteract the effects of ursodiol, but these interactions have not been well studied.[1,3]


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