Pathogenesis and Radiobiology of Brain Arteriovenous Malformations: Implications for Risk Stratification in Natural History and Post-treatment Course

Achal S. Achrol, B.S.; Raphael Guzman, M.D.; Monika Varga, B.S.; John R. Adler, M.D.; Gary K. Steinberg, M.D.; Ph.D.; Steven D. Chang, M.D.

Disclosures

Neurosurg Focus. 2009;26(5):E9 

In This Article

Conclusions

Further investigations are needed to identify the underlying etiology of BAVMs. High-throughput proteomewide approaches promise to provide better insight into global pathways involved in the pathogenesis and radiobiology of BAVM, and identify biomarkers with the potential to address current controversies in the management of unruptured BAVMs. Studies on EPC function represent a promising new area of research that may provide insights into the mechanism of new vessel formation in BAVM and other cerebrovascular diseases. The GWAS may overcome limitations of previous candidate gene investigations in BAVM and holds the potential to uncover underlying mechanisms in BAVM pathogenesis, risk of future ICH, and differential response to SRS.

Insights from future investigations studying BAVMs may not only prove important for the development of novel therapies and relevant biomarkers for BAVM but could also potentially benefit a variety of other disorders involving new vessel formation in the CNS, including stroke, tumors, moyamoya disease, and other cerebrovascular malformations.

Comments

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