Management of Nerve Sheath Tumors Arising in the Sympathetic Chain

Surbhi Jain, MD; Kristin Houseknecht, MPH; Amyn M. Rojiani, MD, PhD; Matthias Setzer, MD; Frank D. Vrionis, MD, MPH, PhD


Cancer Control. 2008;15(4):352-357. 

In This Article


Intraoperative consultations and final diagnosis for all three cases were identical and are described together. The tumors consisted of a typical spindle cell population with modest pleomorphism. Focally hypocellular areas (Antoni type B) were present amid hypercellular spindle cell populations (Antoni type A). Vascular hyalinization and occasional hemosiderin deposits were seen. Immunohistochemistry for S-100 protein was strikingly positive in all three cases, and neurofilament-positive processes were not identified within the body of the tumor. These histologic and immunohistochemical features are characteristic of schwannomas or neurilemmomas (Fig 2A-B).

Figure 2A-B.

Depiction of tumor from case 2. (A) Hypercellular spindle cell areas (Antoni A) with focally hypocellular (Antoni B) regions are shown. Hyalinized vessels are also noted (hematoxylin-eosin, original magnification × 100). (B) The tumor cells are strongly immunoreactive for S-100B protein (hematoxylin-eosin, original magnification × 200).


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