Interactions Between Nonprescription Products and Psychotropic Medications

W. Steven Pray, PhD, DPh


US Pharmacist. 2007;32(11):12-15. 

In This Article

Additive Sedation

Brompheniramine, chlorpheniramine, clemastine, cyclizine, dexbrompheniramine, dimenhydrinate, doxylamine, meclizine, phenindamine, pheniramine, pyrilamine, and triprolidine must carry warnings advising the patient about possible drowsiness if they are taken concurrently with alcohol, sedatives, or tranquilizers.[6] Diphenhydramine products also carry this warning but must state that they can cause "marked drowsiness." These ingredients are found in products indicated for allergic rhinitis, the common cold, motion sickness, insomnia, and menstrual discomfort.

Nonprescription nicotine cessation products carry a specific warning against concurrent use with prescription antidepressants unless the patient first speaks to a physician or pharmacist. This warning appears on nicotine gum, patches, and lozenges and is required because cessation of smoking can increase the plasma concentrations of some antidepressant medications.[6]


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