Chronic Recurrent Multifocal Osteomyelitis: What is it and how Should it be Treated?

Hermann J Girschick; Christiane Zimmer; Guenter Klaus; Kassa Darge; Anke Dick; Henner Morbach


Nat Clin Pract Rheumatol. 2007;3(12):733-738. 

In This Article


CNO includes unifocal and multifocal bone lesions. The latter form is known as CRMO. CRMO and other forms of CNO can evolve into spondyloarthropathy and can involve the skin, eyes, lungs and gastrointestinal tract. NSAIDs are recommended as a first-line therapy; DMARDs, steroids, bisphosphonates and TNF blockers have also been used. Multidisciplinary diagnostic and therapeutic approaches are necessary to cover the clinical variability of CRMO and to ensure that this syndrome is managed effectively.

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