Investigation of the Skin Characteristics in Patients with Severe GH Deficiency and the Effects of 6 Months of GH Replacement Therapy: A Randomized Placebo Controlled Study

Fatih Tanriverdi; Murat Borlu; Hulusi Atmaca; Cagdas Atasavun Koc; Kursad Unluhizarci; Serap Utas; Fahrettin Kelestimur

Disclosures

Clin Endocrinol. 2006;65(5):579-585. 

In This Article

Results

At baseline no significant differences were detected between the patients and the controls in skin PH, TEWL and temperature on forehead and forearm. In patients with GHD median skin sebum content on forehead was significantly lower than healthy controls (P < 0·05), but there was not any difference on forearm. The capacitance measurements on forehead and forearm were significantly lower in the patients with Sheehan's syndrome when compared to the controls (P < 0·05). Baseline measurements of the skin characteristics in the patients with Sheehan's syndrome and in the controls are summarized in Table 2 .

When we compared all the baseline measurements (sebum content, skin capaticance, TEWL, pH and temperature) of the treatment (10 patients with GHD) group to the placebo (6 patients with GHD) group, no significant differences were found between these parameters (data not shown).

In the treatment group there was a significant increase in the serum IGF-I level after 6 months of GHRT compared to median baseline IGF-I level (290 ng/ml, range 214-404, 31 ng/ml, range 6-82, respectively) (P < 0·05). In the placebo group no difference was found between the IGF-I levels at 6 months and at baseline (18 ng/ml, range 5-41, 19 ng/ml range 8-39, respectively).

In the treatment group there was a significant increase in sebum content on forehead after 6 months of GHRT compared to the baseline value (P < 0·05). However there were not any significant changes in other parameters including sebum content on forearm, TEWL, Ph, skin capacitance and temperature on both forearm and forehead ( Table 3 ). When the significant increases of sebum content on the forehead in the treatment group were individually analysed, 9 (90%) of 10 patients showed an increase after 6 months of GHRT (Fig. 1a). In the placebo group there were no changes in all the evaluated parameters after 6 months of treatment when compared to baseline values (data not shown). When the measurements of sebum content on forehead in the placebo group were individually analysed, only 1 patient had a minimal increase after 6 months of placebo treatment (Fig. 1b).

Figure 1.

(a) Individual changes in sebum content on the forehead in the treatment group at baseline and after 6 months of GHRT. (b) Individual changes in sebum content on the forehead in the placebo group at baseline and after 6 months of placebo treatment.

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