Relapsing Polychondritis

Peter D. Kent; Clement J. Michet, Jr; Harvinder S. Luthra

Disclosures

Curr Opin Rheumatol. 2004;16(1) 

In This Article

Disease Associations

As many as 37% of patients with relapsing polychondritis have an associated hematologic disorder, connective tissue disease, vasculitis, dermatologic disorder, or other autoimmune disease[5*,17]:

  • Systemic vasculitis

  • Leukocytoclastic vasculitis

  • Connective tissue diseases

  • Behçet disease

  • Rheumatoid arthritis

  • Juvenile chronic arthritis

  • Spondylarthropathies

  • Myelodysplastic syndromes

  • Hematologic malignancies

  • Cryoglobulinemia

  • Thymoma

  • Retroperitoneal fibrosis

  • Familial Mediterranean fever

  • Inflammatory bowel disease

  • Pernicious anemia

  • Primary biliary cirrhosis

  • Panniculitis

  • Psoriasis

  • Dermatitis herpetiformis

  • Vitiligo

  • Atopic dermatitis

  • Lichen planus

  • Autoimmune thyroid disease

  • Myasthenia gravis

  • Diabetes mellitus

  • Glomerulonephritis[3,4,5*]

A case of relapsing polychondritis was recently described in a patient with both HIV infection and sarcoidosis.[42*] Because of the myriad of disease associations, it has been proposed that relapsing polychondritis be thought of as a syndrome, which can be primary or secondary,[43] akin to antiphospholipid syndrome.

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