TPN is a palliative, but life-saving treatment for patients with terminal and irreversible intestinal failure. During the last decade, intestine transplantation has become the most realistic alternative to prolonged TPN therapy as outcomes have markedly improved as a result of considerable clinical experience, advances in immunosuppression and antimicrobial therapy, and refinements in surgical techniques. Nutritional autonomy can be achieved after successful intestine transplantation, making it the standard therapy for patients with intestinal failure and complications resulting from TPN. Most adults are able to maintain adequate nutrition status and children achieve normal growth. Clinical and nutritional management of the intestine transplant recipient is complex and requires a great deal of expertise. Acute rejection, sepsis, dehydration, and malabsorption are still common problems that influence the recipient's quality of life.


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