An extemporaneously prepared suspension of ursodiol 50 mg/mL in a 1:1 mixture of Ora- Plus and strawberry syrup or Ora- Sweet SF was stable for at least 90 days when stored at 3-5 °C or 23-25 °C.
|a||Urso 250-mg tablets, Axcan Pharma U.S. Inc., Birmingham, AL, lot ET42.|
|b||Ora-Plus, Paddock Laboratories, Minneapolis, MN, lot 5B6216.|
|c||Ora-Sweet SF, Paddock, lot 9D6621.|
|d||Simple Syrup, NF, Humco Laboratory, Texarkana, TX, lot 148610.|
|e||Strawberry fountain syrup, Gordon Food Service, Grand Rapids, MI, lot K553909117.|
|f||2-oz amber prescription bottles with childresistant caps, Owens Illinois Prescription Products. Owens Illinois, OH.|
|g||HPLC pump, Waters Associates, Inc., Milford, MA, model 501.|
|h||Spherisorb ODS-2, 5-µm particle size, 250 x 4.6 mm, P. J. Cobert Associates, Inc., St. Louis, MO.|
|i||Eppendorf CH-30 column heater, P. J. Cobert Associates.|
|j||Variable-volume injector, Waters, model U6K.|
|k||unable absorbance detector, Waters, model 486.|
|l||Integrator-recorder, Hewlett-Packard Company, Avondale, PA, model 3394.|
|m||Ursodiol analytic grade powder, Axcan Pharma U.S., lot 990496.|
|n||Altex pH 41 meter, Beckman Instruments, Irvine, CA.|
Supported in part by a grant from Axcan Pharma U.S. Inc., Birmingham, AL. Presented at the ASHP Midyear Clinical Meeting, Las Vegas, NV, December 5, 2000.
Address correspondence to Dr. Johnson at the College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065.
Am J Health Syst Pharm. 2002;59(4) © 2002 American Society of Health-System Pharmacists
Cite this: Stability of Oral Suspensions of Ursodiol Made From Tablets - Medscape - Apr 01, 2002.