Stability of Oral Suspensions of Ursodiol Made From Tablets

Cary E. Johnson and Darcie D. Streetman

Disclosures

Am J Health Syst Pharm. 2002;59(4) 

In This Article

Conclusion

An extemporaneously prepared suspension of ursodiol 50 mg/mL in a 1:1 mixture of Ora- Plus and strawberry syrup or Ora- Sweet SF was stable for at least 90 days when stored at 3-5 °C or 23-25 °C.

a Urso 250-mg tablets, Axcan Pharma U.S. Inc., Birmingham, AL, lot ET42.
b Ora-Plus, Paddock Laboratories, Minneapolis, MN, lot 5B6216.
c Ora-Sweet SF, Paddock, lot 9D6621.
d Simple Syrup, NF, Humco Laboratory, Texarkana, TX, lot 148610.
e Strawberry fountain syrup, Gordon Food Service, Grand Rapids, MI, lot K553909117.
f 2-oz amber prescription bottles with childresistant caps, Owens Illinois Prescription Products. Owens Illinois, OH.
g HPLC pump, Waters Associates, Inc., Milford, MA, model 501.
h Spherisorb ODS-2, 5-µm particle size, 250 x 4.6 mm, P. J. Cobert Associates, Inc., St. Louis, MO.
i Eppendorf CH-30 column heater, P. J. Cobert Associates.
j Variable-volume injector, Waters, model U6K.
k unable absorbance detector, Waters, model 486.
l Integrator-recorder, Hewlett-Packard Company, Avondale, PA, model 3394.
m Ursodiol analytic grade powder, Axcan Pharma U.S., lot 990496.
n Altex pH 41 meter, Beckman Instruments, Irvine, CA.

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