Amphotericin B Lipid Complex for the Treatment of Recurrent Blastomycosis of the Brain in a Patient Previously Treated With Itraconazole

South Med J. 2001;94(5) 

In This Article

Abstract and Introduction

This is the first reported case of cerebral blastomycosis successfully treated with amphotericin B lipid complex.

Itraconazole is the preferred therapy for blastomycosis not involving the central nervous system. The drug has an efficacy rate of approximately 90% in patients who complete 6 months of therapy.[1] Itraconazole and ketoconazole do not penetrate the central nervous system well, and there are reports of cerebral blastomycosis in patients treated with ketoconazole for pulmonary disease.[2,3] The following is a case of cerebral blastomycosis treated with amphotericin B lipid complex in a patient who had been treated with itraconazole for pulmonary blastomycosis 4 years earlier. This appears to be the first reported case of successful treatment of central nervous system blastomycosis with amphotericin B lipid complex.

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