A variety of other pharmacologic approaches have been described, including estrogens, prostaglandin inhibitors, scopolamine, baclofen, and bromocriptine, with variable success. Cardozo and coworkers reported symptomatic improvement in patients with detrusor instability given indomethecin; however, this was a short-term study without urodynamic results. Cornella and associates demonstrated 30% subjective improvement in detrusor instability symptoms with scopolamine, but 70% of the patients experienced moderate-to-severe side effects and discontinued its use.
© 2000 Cliggott Publishing, Division of CMP Healthcare Media
Cite this: New Pharmacologic and Minimally Invasive Therapies for the Overactive Bladder - Medscape - May 01, 2000.