New Pharmacologic and Minimally Invasive Therapies for the Overactive Bladder

Michael Franks, MD, Emmanuel Chartier-Kastler, MD, Michael B. Chancellor, MD

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Other Drugs

A variety of other pharmacologic approaches have been described, including estrogens, prostaglandin inhibitors, scopolamine, baclofen, and bromocriptine,[36] with variable success. Cardozo and coworkers[37] reported symptomatic improvement in patients with detrusor instability given indomethecin; however, this was a short-term study without urodynamic results. Cornella and associates[38] demonstrated 30% subjective improvement in detrusor instability symptoms with scopolamine, but 70% of the patients experienced moderate-to-severe side effects and discontinued its use.

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