New Pharmacologic and Minimally Invasive Therapies for the Overactive Bladder

Michael Franks, MD, Emmanuel Chartier-Kastler, MD, Michael B. Chancellor, MD

In This Article


There has been a revolution in the treatment of urinary incontinence and the overactive bladder. With the introduction of tolterodine and oxybutynin XL, there are now 2 superior medications that are better tolerated and more effective than traditional anticholinergics. In addition, the investigative technique of intravesical resiniferatoxin promises target-specific and long-lasting therapy in the near future. Paraplegic patients can be offered new and nonablative treatments of overactive bladder that are minimally invasive and may be therapeutically beneficial for autonomic dysreflexia, spasticity, and probably ejaculation improvement. Last, the minimally invasive surgical technique of SNS gives urologists a new procedure to treat refractory urinary incontinence.


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