The Changing Face of Trigeminal Neuralgia

A Narrative Review

Stine Maarbjerg MD, PhD; Rafael Benoliel BDS (Hons)


Headache. 2021;61(6):817-837. 

In This Article

Pretrigeminal Neuralgia

An early form of CTN termed "pretrigeminal neuralgia" (pre-TN) has been reported in 18% of patients with CTN and is characterized by a dull continuous pain in one of the jaws that lasts from days to years.[30] Pre-TN pain often mimics dental pathology leading to possible misdiagnosis.

Our clinical experience confirms that there are cases with highly atypical features that respond to carbamazepine and eventually develop into CTN. However, the lack of clear and consistent diagnostic criteria makes this a problematic entity to recognize; it is usually diagnosed when all other possibilities are exhausted or in retrospect once CTN develops.