Pro-Con Debate

Fibrinogen Concentrate or Cryoprecipitate for Treatment of Acquired Hypofibrinogenemia in Cardiac Surgical Patients

Nadia B. Hensley, MD; Michael A. Mazzeffi, MD, MPH, MSc, FASA


Anesth Analg. 2021;133(1):19-28. 

In This Article

Fibrinogen Concentrate Advantage: Rapid Reconstitution and Longer Shelf Life

Another advantage of fibrinogen concentrate is that it can be rapidly reconstituted and administered to patients. Fibrinogen concentrate can be stored at room temperature and is easily reconstituted in sterile water within 5–10 minutes. After reconstitution, fibrinogen concentrate can be used for up to 24 hours, reducing wastage.[21,22] In contrast, cryoprecipitate is kept frozen, requires 30–45 minutes for thawing, and has a shelf life of only 6 hours after thawing. During massive hemorrhage, thawing time may be detrimental, leading to an additional hemodilution or consumptive coagulopathy, as the minimal fibrinogen is given in other allogeneic blood products. Due to plasma's low fibrinogen content of 500–600 mg per 250 mL, plasma fibrinogen concentration is likely to remain low, while awaiting cryoprecipitate.[31]