Diabetic Foot Ulcers and Osteomyelitis: Use of Biodegradable Calcium Sulfate Beads Impregnated With Antibiotics for Treatment of Multidrug-Resistant Organisms

Prashant Patil, MCh, FDFS; Rajeev Singh, MS; Apurva Agarwal, MS; Rajiv Wadhwa, MS; Aran Bal, MS, PhD; Sanjay Vaidya, MS, MCh


Wounds. 2021;33(3):70-76. 

In This Article


The use of locally released antibiotics from synthetic recrystallized calcium sulfate may offer substantial benefits in the management of infected DFU that is compromised by poor circulation, polymicrobial growth, and associated renal and cardiac comorbidities. The flexibility of combining different antibiotics enables a strategy that is specifically tailored to pathogens. Additionally, this treatment is less expensive and requires fewer resources (eg, no hospital admission required, nursing care not required for 24 hours) than conventional IV antibiotic therapy. The present authors conclude that there is a need for well-designed and adequately powered trials with suitable blinding to investigate whether the use of local antibiotics improves wound healing and reduces the reoperation rate in the management of DFI.