Author, year |
Study groups (n) |
Study Purpose/Degree Collaboration |
Patient Population/Care Setting |
Outcome/Findings |
Study Quality (Score) |
RCTs (n = 14) |
|
|
|
|
|
Becker, 200545 |
NP and community health worker with study MD (196) Enhanced MD PCP primary care (168) |
Determine effectiveness of community-based care provided by NP to that of "enhanced" PCP MD care in managing risk factors for CAD. All MDs and NPs were given prescription drug cards (free study prescriptions) to give to pts. Study MD check of pt records twice per month |
African Americans, 30–59 y/o, sibling of pronands < 60 y/o admitted to 1 of 10 hospitals, no history of CAD, autoimmune disease, immediate life-threatening comorbidity, chronic steroid therapy, or current cancer therapy Urban, community-based care Unknown insurance |
LDL-Ca HDL-C Triglycerides Systolic BPa Diastolic BPa |
High (5) |
Bula, 199960 |
GNP with MD geriatrician (203) Usual MD care not described (184) |
Determine if in-home comprehensive geriatric assessment by an NP prevents functional decline in community-dwelling elders. NP performed annual assessment in home. In collaboration with geriatrician, NP developed recommendations regarding specific problems, health promotion, disease prevention, and self care. GNP made home visits q3 months. Unknown frequency of MD collaboration |
Community dwelling, > 74 y/o, without pre-existing functional impairment, without severe cognitive impairment or terminal illness Urban, home care, Medicare pts |
Functional statusa |
High (5) |
Callahan, 200659 |
GNP with MD collaboration (84) PCP MD only care (69) |
Test effectiveness of collaborative care model using a GNP compared to care from a PCP MD for pts with Alzheimer disease. NP case manager assessed pt; met weekly with team for advice (geriatrician, geropsychiatrist, psychologist); advised caregiver re nonpharmacologic and pharmacologic therapies; educated caregivers re communications skills, coping skills, legal and financial info, exercise Met 2 visits with pt/caregivers 1st mo then 1/month x 12 mo Weekly MD consultation available |
Diagnosed with Alzheimer Community living Has caregiver English speaking Home phone Urban, university, and VAMC-affiliated clinics Government or unknown insurance |
Functional status (ADL) |
High (5) |
Counsell, 200757 |
NP as part of GRACE Team with MD PCP (474) Usual MD PCP care (477) |
Test of effectiveness of geriatric care management including NP delivered care. NPs performed complete geriatric assessment, discussed results at team meeting (social worker, geriatrician), shared selected protocols with PCP for continuity, implemented selected GRACE protocols via monthly face-to-face or phone contacts with pt Pt followed x 1 yr Control group MD PCPs had access to all services (social worker, geriatrician, therapies, etc) except GRACE protocols Unknown frequency of MD consultation |
> 64 y/o Without ESRD or cognitive impairment Community residing English speaking Telephone access Intact hearing Established pt Income < 200% of federal poverty level Urban, home, and community care Unknown insurance |
Physical SF-36 Mental SF-36a Functional status (ADL) ED visitsa Hospitalization |
High (7) |
Fanta, 200633 |
PNP and attending MD (31) Resident MD and attending MD (45) |
Compare care provided by trauma PNP and trauma service house staff. NP replacing resident MDs as provider of all day-to-day assessments and care Daily MD consultation |
Children between 2 mo and 17 y/o Admitted to inpatient trauma service Urban, specialty service at teaching hospital inpatients Unknown insurance |
Length of stay |
Low (3) |
Krichbaum, 200758 |
GNP in collaboration with MD PCP and surgeon (23) MD PCP and surgeon alone, usual care (23) |
Determine effectiveness of a GNP-coordinated model of postoperative care for elders with hip fractures. GNP coordinated postacute care, performed comprehensive assessment, pt and family teaching, care coordination, updated PCP/surgeon. Pt visits 1x/wk x 4 then 2 x/wk x 12; Pt followed x 1 yr (GNP provided no medical care, only nursing care due to restrictions imposed by participating agencies) Unknown frequency of MD consultation |
> 64 y/o Hip fracture repair (DRG 209 or 210) Ambulatory Living at home or in assisted living facilities Urban, community, and home based care Medicare and unknown insurance |
Functional status (ADL/IADL) |
Low (3) |
Lenz, 200446 |
NP as PCP (70) MD as PCP (64) (All PCPs = FT MD faculty at SOM or NP faculty at SON who also practiced PT at respective clinics) |
Comparison of health outcomes in pts assigned to NPs or MDs for primary care. NPs as PCP providing all primary care without MD collaboration 2-year follow up No MD consultation |
Adults from primarily Hispanic community Recent urgent care or ED visit; No current emergent clinical condition No current healthcare provider (Oversampled pts with asthma, DM, and HTN) English or Spanish speaker Urban, ambulatory primary care clinics associated with academic medical center Medicaid |
Systolic BP Diastolic BP HbA1C Pt satisfaction with care |
High (6) |
Lenz, 200247 |
NP as PCP (47) MD as PCP (30) (All PCP = FT faculty at SOM or SON and PT at clinic) |
Compare selected DM care processes and outcomes of NPs and MDs in primary care of adults with DM2. NP as PCP providing all primary care without MD collaboration 2-year follow up No MD consultation |
Adults from primarily Hispanic community DM2 Recent urgent care or ED visit No current emergent clinical condition No current health care provider Adults Urban, ambulatory primary care clinics associated with academic medical center Medicaid |
HgbA1C SF-36 physical and mental health ED visits Hospitalizations |
High (6) |
Litaker, 200355 |
NP with MD PCP collaboration (79) MD PCP alone (78) |
Compare traditional MD-led model of care with collaborative, team-based approach for chronic disease management. NP delegated sole responsibility for implementation of evidence-based guidelines for DM and HTN mgmt; provided pt education on self mgmt; integrated pt preferences, monitored adherence, provided family support, appt reminders, and standardized care documentation forms; consulted/referred pt to MD for problems outside of care guidelines Control group did not use appt reminders or standardized care documentation forms Unknown frequency of MD consultation |
Adults Mild or moderate HTN and NIDDM Without evidence of end organ complications No complex medical conditions Urban, ambulatory primary care Unknown insurance |
HbA1ca Total cholesterol HDLa BP control SF-12: physical and mental health Satisfactiona |
High (8) |
Mundinger, 200048 |
NP group (649) MD group (391) (All PCP = FT faculty at SOM or SON and PT at clinic) |
Compare outcomes for pts assigned to NPs or MDs for follow up and continuing care after ED/urgent care visits. NP as PCP providing all primary care without MD collaboration 6-mo follow up No MD consultation |
Adults from primarily Hispanic community Recent urgent care or ED visit No current emergent clinical condition No current health care provider (Oversampled pts with asthma, DM, and HTN) English or Spanish speaker Urban, ambulatory primary care clinics associated with academic medical center Medicaid |
Pt satisfaction SF physical and mental health Peak flow HgbA1C BP systolic BP diastolica |
High (8) |
Nelson, 199149 |
PNP follow up 24 hours after ED visit (91) Standard ED discharge instructions from MD and PCP usual care (93) (62% pts given follow up appts in discharge instructions) |
Test effectiveness of an NP intervention to improve parental use of early follow up care after ED visits. NP called parents 24 hours after ED visit for acute illness; provider further info re diagnosis and treatment, reinforce follow up instructions and appt info. Avail. 24/7 for any questions No MD consultation |
Children < 8 y/o without chronic illness Presents with parent or caretaker Seen for infectious or emergent condition Telephone access Primary care center as usual source of care Urban, hospital ED Medicaid |
ED visits |
High (7) |
Paez, 200669 |
NP case managed care in collaboration with MD PCP or cardiologist (115) MD PCP or cardiologist alone. Usual care (113) |
Evaluate effects of case management by NP or standard care by PCP or cardiologist MD on lipids in pt with CAD. NP was delegated authority to prescribe for, monitor, and provide all counseling for lipid control; 1st visit within 6 wk revascularization; phone calls to pt, prn; update MD PCPs "regularly" re pt status (4% of NP time spent in this activity) Pt followed x 1 yr Unknown frequency of MD consultation |
Adults undergoing revascularization procedure Urban, community care Unknown insurance (pt paid for medications) |
Cholesterola LDL-Ca |
High (8) |
Pioro, 200134 |
NP with MD medical director (104) House staff MD with attending MD (277) |
Compare resource use and outcomes of general medical pts receiving NP-based care and traditional house staff care. NP replacing resident MDs as provider of all day-to-day assessments and care (admission history and physical exam, care coordination, implement diagnostic and therapeutic plans); to minimize overnight resident influence RN protocol-based care for common problems Daily MD consultation during rounds |
18–69 y/o Admit to general medical units (transfers from ICU not included) Urban, teaching hospital, inpatient 40% private insurance, 50% Medicare or Medicaid, 10% no insurance |
Length of stay Mortality rate Functional status (ADL/IADL) SF-36 physical and mental health |
High (5) |
Stuck, 199561 |
GNP group (170) usual MD care not described (147) |
Determine if in-home comprehensive geriatric assessment by an NP prevents functional decline in community-dwelling elders. NP performed assessment and, in collaboration with geriatrician, made recommended to pt re specific problems, health promotion, disease prevention, self care. GNP made home visits q 3 mo for follow up and monitor adherence and to help pt talk with PCP re issues Unknown frequency of MD consultation |
> 74 y/o Living at home without pre-existing functional impairment Without severe cognitive impairment or terminal illness No impending nursing home admission Urban, home care Medicare |
Functional status (ADL/IADL)a Hospitalizations |
High (8) |
Observational (n = 23) |
|
|
|
|
Ahern, 200450 |
NP with MD hepatologist as needed (35) MD hepatologist alone (26) |
NP follows pts started on Rebetron for chronic hepatitis C, monitors pts, manages side effects, and teaches pts re medication MD available to see clinic pts with NP prn |
> 17 y/o English speaking Acute/chronic hepatitis C With or without cirrhosis; pt naive to treatment, nonresponsive, or relapse to previous treatment Urban, ambulatory primary care Unknown insurance |
SF-36 physical and mental health |
Low (3) |
Aigner, 200451 |
NP and MD internist teams (132) MD internists (71) (all providers affiliated with university teaching hospital) |
Compared outcomes of pts in nursing homes cared for my NP/MD team and MD only practice model. NPs performed annual history and physical exams, acute illness visits, and half the routine intermittent monitoring visits. NPs took first call weekdays. Frequency of MD consultation on a case by case basis |
Residents in 8 nursing homes Unknown communities, long-term care facilities Medicare, Medicaid, and commercial insurance |
Hospitalizations ED visits Length of stay |
Low (4) |
Aiken, 199363 |
NP (30) MD (57) |
Examination of outcomes of care in HIV-infected pts receiving primary care from NPs and MDs. NPs responsible for their own panel of pts and obtained medical histories and performed physical examinations, diagnosed and treated HIV-related illnesses, prescribed meds and monitored for adverse treatment effects, ordered and interpreted diagnostic tests, and provided health education to pts. NPs advised MDs of problems requiring MD intervention. All providers followed the same research and drug protocols. Unknown frequency of MD consultation |
Adult HIV/AIDS pts seen in clinic at least once Urban, ambulatory specialty clinic associated with academic medical center Medicare, Medicaid, and commercial insurance |
Physical functioning (ADL) |
Low (2) |
Bissinger, 199735 |
NNP (35) MD house staff (35) |
Evaluated the clinical outcomes for infants weighing 500–1250 gm cared for by NNPs and those cared for by house staff Unknown frequency of MD consultation |
Neonates with birthweight between 500–1250 gm Admitted to NICU within first 24 hours of life Without identified congenital cardiac, genetic, or surgical conditions Urban, academic medical center-inpatient Unknown insurance |
Length of stay Ventilator duration Mortality |
High (5) |
Borgmeyer 200836 |
PNP added to MD house staff team (29) House staff MD team (28) |
Measure the effectiveness of PNP as direct care manager of children with asthma. PNP performed admission history and physical examination, developed plan of care integrating clinical pathways, document pt progress, participate in daily team rounds, communicate with all team members, teach pts/families and team members re asthma management, develop and execute comprehensive discharge plan Daily MD consultation |
All children admitted to general medical units with exacerbation of asthma Urban, specialty teaching hospital-inpatient Unknown insurance |
Length of stay Hospitalization |
Low (4) |
Dahle, 199837 |
NP and attending MDs (116) Resident and attending MDs (99) |
Evaluated use of NP to manage pts admitted with uncomplicated, decompensated CHF pts in collaboration with attending MDs NPs performed admission history and physical examination and guided therapy implementing protocols in collaboration with attending MDs. Daily MD consultation |
Adults admitted with decompensated heart failure Urban, academic medical center-inpatient Unknown insurance |
Length of stay Hospitalization |
High (5) |
Garrard, 199064 |
NP employee of nursing home (428) Non-NP care in matched nursing home (420) 5 sets of matched nursing homes (match criteria: type ownership; part of chain; Medicare/ Medicaid certification; bed size; urban/rural; state) |
Prospectively evaluated impact of GNPs employed by nursing homes on quality of care and pt outcomes. NPs assumed primary care tasks usually performed by an MD and additional health services in other areas. NPs provided ongoing pt assessment and management Unknown frequency of MD consultation |
Adult Nursing home resident Oriented Unknown communities, long-term care facilities Medicare, Medicaid, commercial, and private pay insurance |
Functional status (ADL) Hospitalizationa |
Low (3) |
Gracias, 200868 |
ACNP and MD intensivist team "closed"' unit (461) MD intensivist team in "semi-closed" unit (919) |
Determine if addition of ACNP and "closed" unit delivery of critical care services would improve compliance to care guidelines and pt outcomes Daily MD consultation |
Adults All pts admitted to 1 of 2 surgical ICUs Urban, academic medical center-inpatient Unknown insurance |
Mortalitya |
High (7) |
Hoffman, 200538 |
ACNP and attending MD team (135) Pulmonary fellows and attending MD team (106) |
Compare outcomes in subacute MICU pts managing managed by ACNP and attending team or pulmonary fellows and attending team. During period on service, either ACNP or MD fellow responsible for new pt admissions processes and consulting attending re diagnoses and plan of care, daily pt assessment, problem diagnosis, writing orders, and making decisions re discharge. Attending MD made daily rounds to review plans and suggest revisions prn. Daily MD consultation |
Adults Admitted to subacute MICU Endotracheal tube intubation Requiring mechanical ventilation for > 24 hours Urban, academic medical center-inpatient Unknown insurance |
Mortalitya Length of stay Duration of ventilation |
High (7) |
Kane, 200452 |
Evercare NP and MD (664) (44 sites) Evercare MD only (855) (44 sites) Other long-term care site (1490) (44 sites) |
Evaluated care outcomes in nursing home residents provided primary care in Evercare NP-led, Evercare MD-led, and traditional MD-led delivery models. NP carries responsibility for a caseload of 100 pts and supplements MD by regularly monitoring pts, responding to changes in condition, and intervening in urgent situations; communicate with pts/families and other providers; work with nursing home staff to improve care Infrequent MD consultation |
Nursing home residents enrolled in Evercare and non Evercare nursing homes Unknown communities, nursing homes Medicare or Evercare HMO |
Mortality Hospitalizationsa |
Low (4) |
Karlowicz, 200039 |
NNP and MD neonatologist (94) Resident and MD neonatologist (107) |
Compare outcomes of health care delivered to extremely low-birthweight infants by NNPs and resident physicians. NNPs performed physical assessments, made medical diagnoses, ordered medications and diagnostic tests, performed invasive procedures (eg, intubation, insertion of arterial and venous catheters) Unknown frequency of MD consultation |
Newborns admitted to NICU Born at study hospital Surviving > 12 hours after birth Without identified chromosomal or congenital malformation Urban, teaching hospital-inpatient Unknown insurance |
Length of stay Mortality |
High (5) |
Kutzleb 200662 |
NP and MD cardiologist (13) MD cardiologist & fellows (10) |
Evaluate impact on pts with heart failure of NP-directed lifestyle modifications (diet, daily weight, smoking cessation, alcohol avoidance, exercise and medication compliance, etc). NPs saw pts in clinic monthly x 12 for physical exam, protocol-based medical therapy, NP-developed individual education plan. NP made weekly calls to follow up with pts. MD cardiologist and fellow group saw pts in clinic quarterly for physical exam, medical therapy as needed, and MD-directed lifestyle modification Unknown frequency of MD consultation |
18–75 y/o with echo documented heart failure English speaking Exclusions: Other life threatening illnesses (eg, cancer); AMI or UA as cause of heart failure; dementia: chronic medication dependent psychiatric mental health condition Urban, community hospital associated clinic Unknown insurance |
Functional status |
Low (2) |
Lambing, 200440 |
NP and MD geriatrician (50) Residents and MD internists (50) |
Compared care activities and clinical outcomes for geriatric pts cared for by NPs on geriatric unit to pts cared for by interns/residents on medical units. NPs performed pt admissions and daily assessments, documented pt progress, planned care, obtained consults, performed procedures, completed discharge planning and pt/family education Daily MD consultation |
Inpatient geriatric pts 60+ y/o Admitted to geriatric unit or 1 of 2 general medical units Urban teaching hospital-inpatient Medicare |
Length of stayb Hospitalization |
Low (4) |
McMullen, 200141 |
ACNP and attending MD (296) Resident and attending MD (405) |
Compare pt outcomes and pt/staff and physician satisfaction with ACNP/attending MD collaborative service and traditional MD-based service Unknown frequency of MD consultation |
Adults admitted to medical unit Urban academic medical center-inpatient Unknown insurance |
Perceived physical healtha Perceived mental health |
Low (4) |
Meyer, 200566 |
ACNP and surgeon team (70) Surgeons alone (145) |
Examine outcomes of pts whose postoperative care was directed by ACNP in collaboration with surgeon or surgeon alone. All surgeons in private practice. All ACNPs hospital employees. ACNPs provided daily and as needed physical exams and assessments, ordered and interpreted diagnostic tests, diagnosed, treated, monitored acute and chronic illnesses, prescribed and managed medications, counseled and taught pts/families regarding nutrition and health promotion, and referred to other providers as needed Unknown frequency of MD consultation |
Adults 1 of 4 cardiovascular surgery DRG Admitted to CVICU from the OR Pt of 1 of 4 usual cardiovascular surgeons Complete computerized record available Urban, private hospital-inpatient |
Length of stay |
High (6) |
Miller, 199767 |
GNP and MD managed (332) PA and MD managed (174) |
Comparison of impact of addition of GNP rather than PA to MD care of older adults. GNP performed admission history and physical examination, made medical diagnoses, and using mutually developed protocols, ordered medical care and pharmaceuticals, and obtained consults.GNP provided pt/family education and developed discharge plans and wrote discharge orders. NP and MD rounded independently daily, and MD rarely made changes to GNP plan of care Unknown frequency of MD consultation |
Nursing home pts admitted to inpatient medical unit Urban, teaching hospital-inpatient on nonteaching service Unknown insurance |
Length of staya |
High (5) |
Paul, 200053 |
NP holds primary responsibility for pt follow up (15) MD holds primary responsibility for pt follow up (15) |
Evaluation of NP-led multidisciplinary heart failure clinic. At every visit NP assessed pt and available test results, ordered appropriate tests, adjusted medications, provided pt/family education. MD saw each pt briefly to bill Medicare for visit. NP called pt between visits to assess status Brief MD consultation available at every visit |
Adults with CHF seen at university hospital-affiliated clinic Unknown communities, ambulatory multidisciplinary clinic associated with academic medical center Unknown insurance |
Hospitalizationa Length of stay ED visits |
Low (3) |
Pinkerton, 200054 |
NP (80) MD (80) |
Compare pt perceived health and satisfaction with care based on whether care provided only by NP or only by MD in managed care setting No MD consultation |
Ambulatory > 18 y/o DM or HTN English speaking Urban, primary care practices associated with teaching hospital Medicaid |
Satisfaction |
High (7) |
Rideout, 200765 |
PNP in addition to MD and nursing team (21) MD and nursing team without PNP (NR) |
Evaluation of inpatient PNP care coordinator for pediatric CF pts; complete admission and daily PE and assessment of care needs; communicate with attending, residents, and nurses; schedule tests and procedures; obtain routine consults; ID and implement plans for infection control; answer pt questions and address concerns; discuss discharge needs and plans with pt; coordinate completion of discharge paperwork Unknown frequency of MD consultation |
Children- young adults Cystic fibrosis Admitted to adolescent unit Urban, university-affiliated specialty hospital-inpatient Unknown insurance |
Length of stay Processes of care Nurse/MD/pt satisfaction |
Low (3) |
Ruiz, 200142 |
WHNP and MD (30) Residents and MD (41) |
Compare newborn outcomes for twins born to mothers receiving care in specialized twin clinic with consistent WHNP providing care using evidence-based protocol developed with perinatologist vs mothers receiving standard prenatal care. WHNPs did intake assessment preterm labor risk, laboratory, and nutritional assessment; created problem list with MD; provided home visits for social support evaluation and preterm labor and lifestyle modification teaching; weekly scored cervical exams and screens for bacterial vaginosis and treated same; reinforced teaching re preterm labor; and intervened re rest, work, and nutritional needs Unknown frequency of MD consultation |
Twin pregnancy referred for care as soon as confirmed by ultrasound or by 24 weeks gestation at latest Urban, primary care practices associated with teaching hospital Unknown insurance |
Length of staya Perinatal mortality |
High (5) |
Russell, 200243 |
ACNP added to neurosurgical team (122) Neurosurgical team alone (402) |
Determine clinical and financial impact of ACNP-led outcomes management program for pts in neuro ICU. NPs performed daily pt assessment, including laboratory and diagnostic test results, presented pt information and plan of care during daily rounds; evaluated pt changes in condition and instituted therapies, medications, and consultations. Developed discharge plan. Daily MD consultation |
> 18 y/o with tracheostomy Admitted to neuro unit after laminectomy or for care of intracerebral hemorrhage or hydrocephalus or for care of subarachnoid hemorrhage or brain tumor, with or without craniotomy Urban, academic medical center-inpatient Unknown insurance |
Mortality Length of stay Duration ventilation |
High (5) |
Schultz, 199444 |
NNP and neonatologist (111) Resident MD and neonatologist (129) |
Evaluation of the effectiveness of NNP in providing direct day-to-day care to infants in Level III NICU compared to resident MDs. NNPs completed admission history, physical examination, and psychosocial assessment; developed medical and nursing plans; prescribed medications; performed procedures; ordered and interpreted labs; responded to acute changes in condition Daily MD consultation |
Infants admitted to transitional care unit Urban, academic medical center-inpatient Unknown insurance |
Length of staya Hospitalization |
High (6) |
Varughese, 200656 |
NP and MD anesthesiologist (77) MD anesthesiologist alone (20) |
Evaluated the effectiveness of using NPs rather than MD anesthesiologists to complete preoperative evaluations Daily MD consultation |
1509 children between 1 mo and 18 y/o scheduled for outpatient surgery Urban, outpatient surgery of specialty hospital Commercial insurance |
Satisfaction |
Low (2) |