Key Reports in Lymphoma CAR T Therapies From ASH 2021

David Miklos, MD

Disclosures

January 06, 2022

Dr David Miklos, of Stanford University, reports on results of three of the most talked-about studies on CAR T-cell therapy in patients with large B-cell lymphoma (LBCL) as presented at this year’s American Society of Hematology annual meeting.

Dr Miklos begins with side-by-side comparisons of the trial schema and promising event-free survival outcomes of the ZUMA-7 and TRANSFORM studies.

He then offers his take on why study design differences led to positive outcomes for LBCL in the axi-cel and liso-cel arms of ZUMA-7 and TRANSFORM, respectively, but a negative outcome for patients with LBCL in the tisa-cel arm of the BELINDA study. All therapies targeted CD19, and all studies shared the aim of moving CAR T-cell therapies from standard-of-care third-line to second-line.

Finally, Dr Miklos discusses therapies that may receive FDA approval and changing approaches to salvage therapy for patients with relapsed and refractory LBCL.

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