Nature Clinical Practice Rheumatology

• Subclinical Carotid Atherosclerosis in a Patient with Systemic Lupus Systemic lupus erythematosus (SLE) is diagnosed in a 41-year-old, previously healthy black woman. What risk factors for subclinical atherosclerosis are present in SLE and how can they be managed?
  Nature Clinical Practice Rheumatology, May 18, 2007
• Does Parathyroid Hormone Treatment Affect Fracture Risk or BMD? PTH peptides have striking anabolic effects on bone at some skeletal sites compared with other treatments for osteoporosis, but issues related to their use in clinical practice remain unresolved.
  Nature Clinical Practice Rheumatology, March 27, 2007
• A Case of Axial Undifferentiated Spondyloarthritis Diagnosis and Management This Case Study describes the diagnosis of axial undifferentiated spondyloarthritis in a young man with inflammatory back pain, and his subsequent management.
  Nature Clinical Practice Rheumatology, March 13, 2007
• Imatinib For The Treatment Of Rheumatic Diseases In this Viewpoint, the authors discuss how imatinib could provide a potent therapeutic option for a variety of autoimmune and inflammatory diseases, for which current therapies are insufficient.
  Nature Clinical Practice Rheumatology, April 01, 2007
• Scleritis And Its Relationship To Systemic Autoimmune Disease In this Review, the authors discuss the clinical presentation, etiology, pathogenesis and treatment of scleritis, an extremely painful condition.
  Nature Clinical Practice Rheumatology, April 01, 2007
• Primer: Demystifying Risk—Understanding And Communicating Medical Risks In this article, the authors explain the risk measures that are commonly used in medical literature and discuss the issues surrounding risk communication.
  Nature Clinical Practice Rheumatology, March 01, 2007
• Functional Staging And Surgical Intervention in RA This Case describes a 43-year old woman with a 23-year history of rheumatoid arthritis and includes a discussion of the functional staging of the patient’s joints and the reasoning behind her surgery.
  Nature Clinical Practice Rheumatology, February 01, 2007
• Establishing The Efficacy Of Traditional Chinese Medicine In this Viewpoint, Dr. Tsang discusses how the efficacy of traditional Chinese medicine could be assessed, and collaboration with clinical scientists trained in TCM and in Western medicine.
  Nature Clinical Practice Rheumatology, February 01, 2007
• Drug Insight: resistance to methotrexate and other DMARDS This article discusses the molecular mechanisms that might be involved in the development of resistance to DMARDS and strategies to overcome this phenomenon.
  Nature Clinical Practice Rheumatology, January 01, 2007
• Opioid Therapy for Refractory Pain in Children with Juvenile RA In this Viewpoint, Dr Connelly and Dr Schanberg discuss the limited knowledge regarding the widespread occurrence of pain and research into treatment with opioids in children with arthritis.
  Nature Clinical Practice Rheumatology, December 01, 2006
• Pathogenesis and Treatment of ANCA-associated Vasculitides A pathogenic role for antineutrophil cytoplasmic autoantibodies in Wegener’s granulomatosis and microscopic polyangiitis, and recent therapeutic developments, are outlined in this review.
  Nature Clinical Practice Rheumatology, December 01, 2006
• Switching Tumor Necrosis Factor Inhibitors: an Opinion Significant numbers of patients demonstrate an inadequate response to one or more TNF inhibitor. In this article, Dr. Keystone discusses the scientific and clinical rationale for switching inhibitors.
  Nature Clinical Practice Rheumatology, November 01, 2006
• Therapy Insight: Osteoporosis and Osteonecrosis in Systemic Lupus Improvements in treatments for systemic lupus erythematosus have led to longer survival times, but complications including osteoporosis and osteonecrosis often occur.
  Nature Clinical Practice Rheumatology, October 01, 2006
• Technology Insight: Imaging of Low Back Pain Improvements in treatments for systemic lupus erythematosus have led to longer survival times, but complications including osteoporosis and osteonecrosis often occur.
  Nature Clinical Practice Rheumatology, October 01, 2006
• Autoimmunity to Protective Molecules This Review discusses the prevalence, actions and clinical significance of these molecules in autoimmune conditions.
  Nature Clinical Practice Rheumatology, September 01, 2006
• A Case of Destructive Wegener’s Granulomatosis This Case Study describes a patient with Wegener's granulomatosis and inflammatory destruction of the osseous palate
  Nature Clinical Practice Rheumatology, September 01, 2006
• New Antinuclear Antibody Testing In this Practice Point Commentary, Dr Wallace discusses the recently published findings on a new, automated test, the ELiA Symphony.
  Nature Clinical Practice Rheumatology, August 01, 2006
• Recognition and Treatment of Retinal Manifestations of Systemic Vasculi This Review describes the pathogenesis, clinical features and treatment of retinal manifestations of systemic vasculitides.
  Nature Clinical Practice Rheumatology, August 01, 2006
• Fibromyalgia—A Different Type of Pain This Review describes a multimodal approach to treating this central pain syndrome, using neuroactive drugs that modulate sensory processing.
  Nature Clinical Practice Rheumatology, July 01, 2006
• Severe Uveitis in an HLA-B27-positive Patient With Ankylosing Spondylitis This Case Study describes an atypically severe attack of uveitis in a patient with HLA-B27-positive ankylosing spondylitis.
  Nature Clinical Practice Rheumatology, July 01, 2006