What is serrated polyposis (hyperplastic polyposis syndrome)?

Updated: Jun 06, 2020
  • Author: Jaime Shalkow, MD, FACS; Chief Editor: Cameron K Tebbi, MD  more...
  • Print


This syndrome, also known as hyperplastic polyposis syndrome, has an unknown molecular etiology and inheritance pattern, arising mostly as a sporadic syndrome; it confers a 35% risk of colorectal cancer. [33]

The colonoscopic criteria for this syndrome include one of the following:

  • At least 5 histologically confirmed serrated polyps proximal to the sigmoid colon, with at least 2 being greater than 1 cm.

  • Any number of serrated polyps proximal to the sigmoid colon, in a patient with a first-degree relative diagnosed with serrated polyposis syndrome.

  • More than 20 serrated polyps scattered throughout the entire colon.

In order to prevent malignancy in these patients, complete colonoscopic detection and resection of polyps should be performed. In cases in which this is not feasible, surgical resection is recommended. [5]

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!