What are the treatment guidelines for VIPomas?

Updated: Feb 12, 2019
  • Author: Cameron K Tebbi, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Recommendations for treatment of NETs that secrete vasoactive intestinal peptide (VIPomas) include the following:

  • Stabilize with IV fluids; correct electrolyte imbalance

  • Tumors located in the head of the pancreas: Pancreatectomy with resection of peripancreatic lymph nodes

  • Distal tumors: Distal pancreatectomy with splenectomy and resection of peripancreatic lymph nodes.

The North American Neuroendocrine Tumor Society (NANETS) guidelines and the European Society for Medical Oncology (ESMO) guidelines for treatment of neuroendocrine pancreatic tumors are similar to those of the NCCN, with some minor variances. The ESMO guidelines do not recommend laparoscopic resection or surgical treatment of G2 pancreatic NETs. [115]

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