What are the NCCN recommendations for the treatment of insulinoma?

Updated: Feb 12, 2019
  • Author: Cameron K Tebbi, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Answer

Recommendations for insulinoma treatment include the following:

  • Stabilize glucose levels with diet and/or diazoxide; everolimus may be considered

  • Primary treatment is enucleation; consider laparoscopic resection for solitary tumors

  • Deeper or invasive tumors or those with proximity to the main pancreatic duct require pancreatoduodenectomy if located in the head and laparoscopic distal pancreatectomy if in a distal location, with preservation of the spleen for smaller tumors


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