What are the UK and Ireland Neuroendocrine Tumour Society (UKI NETS) recommendations for grading and staging of carcinoid tumors?

Updated: Feb 12, 2019
  • Author: Cameron K Tebbi, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Answer

In 2012, the UK and Ireland Neuroendocrine Tumour Society (UKI NETS) released updated guidelines for the management of GEP-NETs. Recommendations for grading and staging are as follows [106] :

  • For grading: WHO 2010 grading system

  • For staging: 7th edition of the AJCC Cancer Staging Manual

  • Also stage NETs of the stomach, pancreas and appendix with the ENETS site-specific T-staging system

  • The TNM classification used should be specified

  • Underlying features of the T-stage classification (eg, tumor size, extent of invasion) should be documented to allow for translation between different classification systems

In 2013, the North American Neuroendocrine Tumor Society (NANETS) concluded that while the criteria differ among the various classification systems, the underlying data are similar and pathology reports should include notation of the systems and parameters used to assign the grade and stage. [36]


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